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Novel lysosome-targeted anticancer fluorescent agents used in zebrafish and nude mouse tumour imaging

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 1,   Pages 112-120 doi: 10.1007/s11705-021-2075-5

Abstract: The design of three novel fatty nitrogen mustard-based anticancer agents with fluorophores incorporated

Keywords： fluorescent drug     lysosomal     anticancer     zebrafish     nude-mouse tumour imaging    

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Progress in tumor vascular normalization for anticancer therapy: challenges and perspectives

Bingxue Shang, Zhifei Cao, Quansheng Zhou

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 67-78 doi: 10.1007/s11684-012-0176-8

Abstract: disorganized tumor vasculature, rather than disrupting or blocking them, has emerged as a new option for anticancerHowever, current tumor vascular normalizing drugs display moderate anticancer efficacy.provide a good opportunity for discovering novel tumor vascular normalizing drugs for an effective anticancer

Keywords： angiogenesis     vasculogenesis     neovascularization     tumor     vasculature     normalization     traditional Chinese medicine    

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Synthesis and anticancer activity of (+)-nopinone-based 2-amino-3-cyanopyridines

Shengliang LIAO,Shibin SHANG,Minggui SHEN,Xiaoping RAO,Hongyan SI,Jie SONG,Zhanqian SONG

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 4,   Pages 335-340 doi: 10.15302/J-FASE-2015079

Abstract: All the compounds were tested for their anticancer activity against lung cancer cell line A549, gastricThe results showed that compounds 4f, 4j and 4k had promising anticancer activity against these cancercell lines, in particular, compound 4f exhibited broad-spectrum and highly efficient anticancer activityBr or Cl substituted group of the benzene ring in these derivatives significantly contributed to the anticancer

Keywords： b-pinene     nopinone     synthesis     2-amino-3-cyanopyridine     anticancer    

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Ozonation of the 5-fluorouracil anticancer drug and its prodrug capecitabine: Reaction kinetics, oxidation

Siyu Chen, Lee Blaney, Ping Chen, Shanshan Deng, Mamatha Hopanna, Yixiang Bao, Gang Yu

Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 4, doi: 10.1007/s11783-019-1143-2

Abstract:

Specific second-order rate constants were determined for 5-FU and CAP with ozone.

Reaction sites were confirmed by kinetics, Fukui analysis, and products.

The olefin moiety was the main ozone reaction site for 5-FU and CAP.

Carboxylic acids comprised most of the residual TOC for 5-FU.

Ozonation removed the toxicity associated with 5-FU and products but not CAP.

Keywords： Ozone     5-fluorouracil     Capecitabine     Hydroxyl radicals     Chemotherapy agents     Toxicity    

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Product identification and toxicity change during oxidation of methotrexate by ferrate and permanganate in water

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 7, doi: 10.1007/s11783-021-1501-8

Abstract:

• Oxidation of methotrexate by high-valent metal-oxo species was first explored.

Keywords： Anticancer drugs     High-valent metal-oxo species     Oxidation kinetics     Reaction mechanisms     Multi-endpoint    

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Title Author Date Type Operation

Novel lysosome-targeted anticancer fluorescent agents used in zebrafish and nude mouse tumour imaging

Journal Article

Progress in tumor vascular normalization for anticancer therapy: challenges and perspectives

Bingxue Shang, Zhifei Cao, Quansheng Zhou

Journal Article

Synthesis and anticancer activity of (+)-nopinone-based 2-amino-3-cyanopyridines

Shengliang LIAO,Shibin SHANG,Minggui SHEN,Xiaoping RAO,Hongyan SI,Jie SONG,Zhanqian SONG

Journal Article

Ozonation of the 5-fluorouracil anticancer drug and its prodrug capecitabine: Reaction kinetics, oxidation

Siyu Chen, Lee Blaney, Ping Chen, Shanshan Deng, Mamatha Hopanna, Yixiang Bao, Gang Yu

Journal Article

Product identification and toxicity change during oxidation of methotrexate by ferrate and permanganate in water

Journal Article